Several researchers have recently published work using PEI Prime™ to study prostate cancer, Alzheimer's disease, and neuronal cell epigenetics.
Researchers at the Institute of Oncology Research published a paper in Nature Communications using PEI Prime™ to prepare Lentiviruses for infection of LNCap Cells. This cell line is commonly used in prostate cancer research. The cells were infected with a vector containing a gene unregulated in the progression of prostate cancers. This open-access paper is available here.
A collaboration between Seoul National University and University of Texas Southwestern Medical Center used PEI Prime™ to perform a high-throughput screen for cDNAs that regulate gamma-secretase. Gamma-secretase is a a protein linked to amyloid accumulation in Alzheimer’s disease. Their work identified a new positive regulator of gamma-secretase. This open-access paper is available from Cell Reports here.
Researchers at Kyushu University used PEI Prime™ to transfect Neuro2a cells, a model system for investigating neuronal cell function. The research focused on epigenetic regulation of neuronal cells. The advance publication by J-Stage is available here.
Finally, the Ferreira Lab of Medical University of South Carolina published a Second-Generation Lentiviral Production Protocol using PEI Prime™. The protocol is an excellent resource for anyone looking to prepare Lentiviruses using PEI Prime™. The full protocol is available from the Ferreira Lab's website here.
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